Shimadzu’s integrated LC system has been reborn as i-Series Plus. Equipped with ACTO technology for even smoother migration of existing analytical methods, the Nexera-i MT method transfer system allows for easy method transfer between HPLC and UHPLC. Compatible with the method scouting system, method development can now be performed on an integrated LC system. Using i-Series Plus substantially improves method development efficiency, since i-Series Plus can be used to perform method development via rapid UHPLC analysis followed by method migration to HPLC systems at manufacturing departments. The autosampler is also equipped with a simple automated pretreatment function, which is capable of automated sample dilution, reagent addition, and co-injection analysis, to improve the efficiency of sample preparation operations.